Stress hyperglycemia: A prospective study examining the relationship between glucose, cortisol and diabetes in myocardial infarction

We aimed to explore the relationship between stress, hyperglycemia and diabetes in myocardial infarction (MI), using serum cortisol as a surrogate marker for the severity of stress. Subjects with acute MI were prospectively recruited upon hospital admission. Serum glucose and cortisol were measured...

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Published in:Journal of diabetes and its complications 2019-04, Vol.33 (4), p.329-334
Main Authors: Cheung, N. Wah, Wong, K.Y. Carmen, Kovoor, Pramesh, McLean, Mark
Format: Article
Language:English
Subjects:
Chromium
Cortisol
Diabetes
Diabetes mellitus
Enzymes
Fasting
Gender
Glucose
Heart attacks
Hormones
Hyperglycemia
Immunoassay
Metabolism
Myocardial infarction
Stress hyperglycemia
Variables
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container_title Journal of diabetes and its complications
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creator Cheung, N. Wah
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description We aimed to explore the relationship between stress, hyperglycemia and diabetes in myocardial infarction (MI), using serum cortisol as a surrogate marker for the severity of stress. Subjects with acute MI were prospectively recruited upon hospital admission. Serum glucose and cortisol were measured in addition to standard testing. Subjects were defined as having stress hyperglycemia (SH) if they had an admission glucose ≥7.8 mmol/L without a history of glucose intolerance. Subjects were followed up with glucose tolerance testing post-discharge. Of the 200 subjects in the study, 58 had known diabetes/impaired glucose tolerance (IGT), and 45 had SH. There was a positive association between admission glucose and cortisol for the entire cohort (rs = 0.26, p 
doi_str_mv 10.1016/j.jdiacomp.2018.12.015
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This relationship was present in the subgroup who had SH and then normal glucose post-discharge (rs = 0.53, p = 0.03), but not in SH subjects who had diabetes/IGT on post-discharge testing. It was also evident amongst all subjects with normal glucose (rs = 0.46, p &lt; 0.01), but not those with diabetes/IGT in general. On multivariate analysis, admission glucose was a positive predictor and cortisol a negative predictor of abnormal glucose tolerance. 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identifier ISSN: 1056-8727
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source ScienceDirect Freedom Collection 2022-2024
subjects Chromium
Cortisol
Diabetes
Diabetes mellitus
Enzymes
Fasting
Gender
Glucose
Heart attacks
Hormones
Hyperglycemia
Immunoassay
Metabolism
Myocardial infarction
Stress hyperglycemia
Variables
title Stress hyperglycemia: A prospective study examining the relationship between glucose, cortisol and diabetes in myocardial infarction
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