Clinical outcomes of patients with active rheumatoid arthritis with normal acute phase reactant values

Aim Despite high clinical disease activity, some patients with active rheumatoid arthritis (RA) have normal acute phase reactant (APR) values. This study aimed to determine the clinical outcomes of active RA patients with normal APR values. Method Of 5376 patients with RA enrolled in the Korean obse...

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Bibliographic Details
Published in:International journal of rheumatic diseases 2019-05, Vol.22 (5), p.852-859
Main Authors: Chung, Min Kyung, Park, Bohyun, Kim, In Je, Cho, Soo‐Kyung, Kim, Dam, Sung, Yoon‐Kyoung, Choi, Chan‐Bum, Choe, Jung‐Yoon, Chung, Won Tae, Hong, Seung‐Jae, Kim, Tae‐Hwan, Koh, Eunmi, Lee, Shin‐Seok, Yoon, Bo Young, Park, Hyesook, Bae, Sang‐Cheol, Lee, Jisoo
Format: Article
Language:English
Subjects:
active
Acute-Phase Proteins - analysis
acute‐phase protein
Antirheumatic Agents - adverse effects
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - diagnosis
Arthritis, Rheumatoid - drug therapy
Biological Products - adverse effects
Biological Products - therapeutic use
Biomarkers - blood
Clinical outcomes
Disability Evaluation
Erythrocyte sedimentation rate
Female
Health risk assessment
Humans
Male
Middle Aged
normal
Registries
Remission
Republic of Korea
Rheumatoid arthritis
Severity of Illness Index
Time Factors
Treatment Outcome
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Summary:Aim Despite high clinical disease activity, some patients with active rheumatoid arthritis (RA) have normal acute phase reactant (APR) values. This study aimed to determine the clinical outcomes of active RA patients with normal APR values. Method Of 5376 patients with RA enrolled in the Korean observational study network for arthritis (KORONA) registry, 400 patients with disease duration of 2.8 at baseline, biologic‐naïve, and erythrocyte sedimentation rate (ESR) and C‐reactive protein (CRP) drawn at both baseline and 2‐year follow‐up visits were identified. Patients were grouped according to baseline APR levels: normal APRs, one APR elevated, and both APRs elevated. Results Baseline tender and swollen joint counts, mean CDAI and Health Assessment Questionnaire‐Disability Index (HAQ‐DI) scores were significantly lower in the normal APRs group compared with APR‐elevated groups (P 
ISSN:1756-1841
1756-185X
DOI:10.1111/1756-185X.13469