Late Neutrophil Priming Following a Single Session of High-intensity Interval Exercise

Abstract This study evaluated the effect of an acute high-intensity interval exercise (HIIE) session on the function of human neutrophils. Twelve sedentary men performed a HIIE session (8 bouts of 60 s at 90% of peak power, intercalated with 75 s of active recovery at 30 W). Neutrophils were collect...

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Bibliographic Details
Published in:International journal of sports medicine 2019-03, Vol.40 (3), p.171-179
Main Authors: de Oliveira Ottone, Vinícius, Costa, Karine Beatriz, Tossige-Gomes, Rosalina, de Matos, Mariana Aguiar, Brito-Melo, Gustavo, Magalhaes, Flavio de Castro, Esteves, Elizabethe Adriana, Amorim, Fabiano, Rocha-Vieira, Etel
Format: Article
Language:English
Subjects:
Adult
Cytokines - blood
High-Intensity Interval Training
Humans
Interleukin-8 - blood
L-Lactate Dehydrogenase - blood
Male
Muscle, Skeletal - metabolism
Neutrophils - metabolism
Oxidation-Reduction
Phagocytosis
Physiology & Biochemistry
Reactive Oxygen Species - metabolism
Young Adult
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Summary:Abstract This study evaluated the effect of an acute high-intensity interval exercise (HIIE) session on the function of human neutrophils. Twelve sedentary men performed a HIIE session (8 bouts of 60 s at 90% of peak power, intercalated with 75 s of active recovery at 30 W). Neutrophils were collected before, 30 min and 24 h after the exercise session for the evaluation of phagocytic capacity, expression of phagocytic receptors, reactive oxygen species generation, and redox status. 24 h after the HIIE session, an increase was observed in both neutrophil phagocytic capacity and yeast-induced generation of reactive oxygen species, which indicates neutrophil priming in response to an acute HIIE session. Neutrophils also presented an increase in superoxide dismutase activity 24 h after the exercise. Improvement in neutrophil function was accompanied by increased serum levels of IL-8 and increased concentration of plasma lactate dehydrogenase. Our findings show a late activating effect of one HIIE session on neutrophils. We propose that priming of neutrophils by HIIE may play a role in skeletal muscle inflammation after exercise.
ISSN:0172-4622
1439-3964
DOI:10.1055/a-0810-8533