Epidemiology and trends of anaphylaxis in the United States, 2004‐2016

Background No national study has examined the epidemiology of anaphylaxis after introduction of the codes of the International Statistical Classification of Diseases and Health Related Problems, Tenth Revision, Clinical Modification (ICD‐10 CM). Our objective was to examine the trends in incidence a...

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Bibliographic Details
Published in:International forum of allergy & rhinology 2019-06, Vol.9 (6), p.607-614
Main Authors: Chaaban, Mohamad R., Warren, Zachary, Baillargeon, Jacques G., Baillargeon, Gwen, Resto, Vicente, Kuo, Yong‐Fang
Format: Article
Language:English
Subjects:
allergens
anaphylaxis
Anaphylaxis - epidemiology
Anaphylaxis - etiology
Databases, Factual
Female
food allergy
Hospitalization - statistics & numerical data
Hospitalization - trends
Humans
Incidence
International Classification of Diseases
Male
medication allergy
Multivariate Analysis
Retrospective Studies
Risk Factors
United States - epidemiology
venom anaphylaxis
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Summary:Background No national study has examined the epidemiology of anaphylaxis after introduction of the codes of the International Statistical Classification of Diseases and Health Related Problems, Tenth Revision, Clinical Modification (ICD‐10 CM). Our objective was to examine the trends in incidence and hospitalization rates in the United States utilizing ICD‐9 and ICD‐10 CM codes. Methods We used the Clinformatics database from 2004 to 2016. Our outcome measures included incidence of anaphylaxis and hospitalization trends. Multivariable logistic regression was used to assess the predictors of anaphylaxis and hospitalization. Results There were a total of 462,906 anaphylaxis cases. The incidence increased from 153 in 2004 to 218 in 2016 (per 100,000). Women were 1.19 (95% confidence interval, 1.18‐1.20) times more likely to present with anaphylaxis. Medication‐induced anaphylaxis increased 15‐fold. Conclusion This is the first population‐based study that included ICD‐10 CM codes to describe the epidemiology of anaphylaxis in the United States. ICD‐10 codes improved the accuracy of medication‐induced anaphylaxis, the most likely etiology to result in hospitalization.
ISSN:2042-6976
2042-6984
DOI:10.1002/alr.22293