Chronic regional intestinal inflammatory disease: A trans-species slow infection?

•Chronic enteritis throughout mammal species fit in a common pathological framework.•Pathological framework matches a definition of slow infection.•Unspecific innate response to infectious agent could explain pathological features.•Filling the gaps in proposed framework could confirm the mycobacteri...

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Bibliographic Details
Published in:Comparative immunology, microbiology and infectious diseases microbiology and infectious diseases, 2019-02, Vol.62, p.88-100
Main Authors: Balseiro, Ana, Perez, Valentin, Juste, Ramon A.
Format: Article
Language:English
Subjects:
Animals
Causation
Chronic Disease
Chronic infection
Chronic regional inflammatory intestinal disease
Histopathological pattern
Humans
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - diagnosis
Inflammatory Bowel Diseases - epidemiology
Inflammatory Bowel Diseases - etiology
Inflammatory Bowel Diseases - therapy
Inflammatory diseases
Intestine
Literature reviews
Mammal enteritis
Mammals
Mycobacterium avium subsp. paratuberculosis
Paratuberculosis
Primates
Rabbits
Species Specificity
Ulcerative colitis
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Summary:•Chronic enteritis throughout mammal species fit in a common pathological framework.•Pathological framework matches a definition of slow infection.•Unspecific innate response to infectious agent could explain pathological features.•Filling the gaps in proposed framework could confirm the mycobacterial IBD hypothesis. Crohn’s disease and ulcerative colitis in humans and paratuberculosis in domestic and wild ruminants can be defined as chronic regional intestinal inflammatory diseases (CRIID). This review is a literature overview on these diseases in humans, non-human primates, dogs, cats, rabbits, equids and ruminants with a focus on pathological and microbiological features aimed identifying common characteristics that could lead to a unified pathological classification for a better understanding of their mechanisms and causes. The result is a framework of inflammatory forms throughout the different species indicative of common mechanisms of the slow infection type characterized by a time course varying from weeks to months or even years, and where the inflammatory component would be more prominent in the intestinal interphase between host and environment and be morphologically characterized by an infiltrate ranging from lymphoplasmacytic to histiocytic. This should provide new insights for causation demonstration and therapeutic approaches in human IBD.
ISSN:0147-9571
1878-1667
DOI:10.1016/j.cimid.2018.12.001