Effects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders

• Published in: Psychiatry research 2019-03, Vol.273, p.575-577
• Main Authors: Carvalho, Carolina Muniz, Pan, Pedro M., Ota, Vanessa K., Spindola, Letícia M., Xavier, Gabriela, Santoro, Marcos L., Mazzotti, Diego R., Pellegrino, Renata, Hakonarson, Hakon, Rohde, Luis Augusto, Miguel, Euripedes Constantino, Gadelha, Ary, Bressan, Rodrigo A., Belangero, Sintia I.
• Format: Article
• Language: English
• Subjects: Adolescent; Adolescent Behavior - psychology; Brazil - epidemiology; Child; Child Abuse - psychology; Child Abuse - trends; Child maltreatment; Female; Gene-Environment Interaction; G × E-interaction; Humans; Male; Neurodevelopmental Disorders - epidemiology; Neurodevelopmental Disorders - genetics; Neurodevelopmental Disorders - psychology; Polymorphism, Single Nucleotide - genetics; Prospective Studies; Psychopathology
• ISSN: 0165-1781; 1872-7123
• DOI: 10.1016/j.psychres.2019.01.078

•SNPs were not associated to mental disorders or psychopathology in children.•Candidate genes were not associated with increased risk to develop mental disorders.•G × E was not associated to risk of develop mental disorder/psychopathology in children. We evaluated the effects of the interaction between child maltreatment (CM) and single nucleotide polymorphisms (SNPs) on development of mental disorders (MD) and psychopathology. We genotyped 720 individuals from a Brazilian community school-based prospective study, focusing on SNPs in 21 genes known to be associated with mental disorders. CM was assessed via a multi-informant-measure, which was previously validated. To test G × CM, we used linear or logistic models depending on variable evaluated (MD or dimensional psychopathology). After Bonferroni multiple comparison correction, we did not find any statistically significant association of G × CM with either MD or psychopathology.