A Photo‐responsive Small‐Molecule Approach for the Opto‐epigenetic Modulation of DNA Methylation

Controlling the functional dynamics of DNA within living cells is essential in biomedical research. Epigenetic modifications such as DNA methylation play a key role in this endeavour. DNA methylation can be controlled by genetic means. Yet there are few chemical tools available for the spatial and t...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-05, Vol.58 (20), p.6620-6624
Main Authors: Nguyen, Ha Phuong, Stewart, Sabrina, Kukwikila, Mikiembo N., Jones, Sioned Fôn, Offenbartl‐Stiegert, Daniel, Mao, Shiqing, Balasubramanian, Shankar, Beck, Stephan, Howorka, Stefan
Format: Article
Language:English
Subjects:
Catalysis
Catalytic activity
Communication
Communications
cytosine
Deoxyribonucleic acid
DNA
DNA methylation
DNA Methylation - genetics
Epigenesis, Genetic - genetics
Epigenetics
Genomes
Humans
methylation
Modulation
Organic chemistry
Pharmacology
photo-caging
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