High‐fat diet aggravates the liver disease caused by periodontitis in rats

Background Periodontitis is an inflammatory disease that causes periodontium and hepatic alterations. Liver disease is related to the intake of foods rich in fat and sugars (high‐fat). The objective of this study was to evaluate whether a high‐fat diet can aggravate the liver disease caused by ligat...

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Published in:Journal of periodontology (1970) 2019-09, Vol.90 (9), p.1023-1031
Main Authors: Andrade, Raissa Silva Bacelar de, França, Luiz Felipe de Carvalho, Pessoa, Larissa dos Santos, Landim, Bruno de Almeida Arrais, Rodrigues, Ayane Araújo, Alves, Even Herlany Pereira, Lenardo, David Di, Nascimento, Hélio Mateus Silva, Sousa, Francisca Beatriz de Melo, Barbosa, André Luiz dos Reis, Medeiros, Jand‐Venes Rolim, Vasconcelos, Any Carolina Cardoso Guimarães, Vasconcelos, Daniel Fernando Pereira
Format: Article
Language:English
Subjects:
Alanine Transaminase
Animals
Aspartate Aminotransferases
Dentistry
diet
diet therapy
Diet, High-Fat
fatty liver
Female
Liver Diseases
periodontal diseases
periodontal medicine
Periodontitis
Rats
Rats, Wistar
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Summary:Background Periodontitis is an inflammatory disease that causes periodontium and hepatic alterations. Liver disease is related to the intake of foods rich in fat and sugars (high‐fat). The objective of this study was to evaluate whether a high‐fat diet can aggravate the liver disease caused by ligature‐induced periodontitis in rats. Methods Twenty‐one female rats were divided into three groups (n = 7 in each group): control; periodontitis (periodontitis induced with ligature) and high‐fat + periodontitis (received hypercaloric diet and induction of periodontitis). The rats were submitted to the analyses of the following periodontal parameters: gingival bleeding index (GBI), probing pocket depth (PPD), tooth mobility (TM), and alveolar bone height. In the hepatic tissue, the levels of malondialdehyde (MDA), glutathione (GSH), total cholesterol, and myeloperoxidase activity (MPO) were measured. Liver samples were also histopathologically evaluated. Finally, blood levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose, total cholesterol, cholesterol high‐density lipoprotein (HDL), and uric acid were measured. Results The high‐fat + periodontitis group presented an increase in the steatosis score (P 
ISSN:0022-3492
1943-3670
DOI:10.1002/JPER.18-0564