ULK1 polymorphisms confer susceptibility to pulmonary tuberculosis in a Chinese population

OBJECTIVE: The autophagy pathway is a critical process in Mycobacterium tuberculosis infection, and can be regulated by uncoordinated 51-like kinase 1 (ULK1). We investigated the associations between single-nucleotide polymorphisms (SNPs) in ULK1 and risk of tuberculosis (TB) in a Chinese Han popula...

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Bibliographic Details
Published in:The international journal of tuberculosis and lung disease 2019-02, Vol.23 (2), p.265-271
Main Authors: Zhang, R-R., Liang, L., Chen, W-W., Wen, C., Wan, B-S., Luo, L-L., Zhao, Y-L., Chen, J., Yue, J.
Format: Article
Language:English
Subjects:
Adult
Alleles
Asian Continental Ancestry Group - genetics
Autophagy
Autophagy - genetics
Autophagy-Related Protein-1 Homolog - genetics
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Intracellular Signaling Peptides and Proteins - genetics
Male
Middle Aged
Parameter estimation
Phagocytosis
Polymorphism, Single Nucleotide
Risk
Risk management
Single-Nucleotide Polymorphism
Susceptibility
Tuberculosis
Tuberculosis - epidemiology
Tuberculosis - genetics
Tuberculosis, Pulmonary - epidemiology
Tuberculosis, Pulmonary - genetics
Young Adult
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Summary:OBJECTIVE: The autophagy pathway is a critical process in Mycobacterium tuberculosis infection, and can be regulated by uncoordinated 51-like kinase 1 (ULK1). We investigated the associations between single-nucleotide polymorphisms (SNPs) in ULK1 and risk of tuberculosis (TB) in a Chinese Han population.DESIGN: We recruited 380 pulmonary tuberculosis (PTB) cases, 242 extra-pulmonary tuberculosis (EPTB) cases and 606 healthy controls from a Chinese Han population and sequenced ULK1. Five SNPs in ULK1 were selected to investigate the correlations between ULK1 polymorphisms and TB susceptibility.RESULTS: The rs7138581 C allele was associated with a reduced risk of PTB (P = 0.001), whereas the rs9481 A allele was associated with an increased risk (P = 0.025). The rs7138581 CG genotype was significantly associated with a low risk of PTB, with a higher PTB disease severity in clinical parameters. Estimation of haplotype frequencies in ULK1 revealed a protective haplotype CCGAA (P = 0.007) and a potential risk haplotype TGAAA (P = 0.010) for PTB.CONCLUSION: These results demonstrated that ULK1 polymorphisms have significant associations with susceptibility to PTB.
ISSN:1027-3719
1815-7920
DOI:10.5588/ijtld.18.0174