Genome-wide association study of the level of blood components in Pekin ducks

• Published in: Genomics (San Diego, Calif.) Calif.), 2020-01, Vol.112 (1), p.379-387
• Main Authors: Zhu, Feng, Cui, Qian-Qian, Yang, Yu-ze, Hao, Jin-Ping, Yang, Fang-Xi, Hou, Zhuo-Cheng
• Format: Article
• Language: English
• Subjects: Blood components; GWAS; Pekin duck; Serum electrolytes; Serum lipid; Serum protein
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1016/j.ygeno.2019.02.017

Blood components are considered to reflect nutrient metabolism and immune activity in both humans and animals. In this study, we measured 12 blood components in Pekin ducks and performed genome-wide association analysis to identify the QTLs (quantitative trait locus) using a genotyping-by-sequencing strategy. A total of 54 QTLs were identified for blood components. One genome-wide significant QTL for alkaline phosphatase was identified within the intron-region of the OTOG gene (P = 1.31E-07). Moreover, 21 genome-wide significant SNPs for the level of serum cholinesterase were identified on six different scaffolds. In addition, for serum calcium, one genome-wide significant QTL was identified in the upstream region of gene RAB11B. These results provide new markers for functional studies in Pekin ducks, and several candidate genes were identified, which may provide additional insights into specific mechanisms for blood metabolism in ducks and their potential application for duck breeding programs. •This study is the first to show that BCHE gene may be related to fat percentage in ducks.•Some serum lipids were found to have moderate and high heritabilities in ducks.