Characterization and in vitro evaluation of chitosan/konjac glucomannan bilayer film as a wound dressing

[Display omitted] •A two-step casting technique was used to prepare KGM/CHI bilayer films.•The bilayer films preserved the physicochemical properties of each polymer.•The two polymers presented good thermostability and miscibility.•The bilayer films exhibit low cytotoxicity and inhibit microbial pen...

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Bibliographic Details
Published in:Carbohydrate polymers 2019-05, Vol.212, p.59-66
Main Authors: Gomes Neto, Reginaldo Jose, Genevro, Giovana Maria, Paulo, Letícia de Almeida, Lopes, Patrícia Santos, de Moraes, Mariana Agostini, Beppu, Marisa Masumi
Format: Article
Language:English
Subjects:
Bandages
Bilayer film
Biomaterials
Biopolymers
Blend film
Candida albicans - drug effects
Candida albicans - physiology
Casting
Chitosan - chemical synthesis
Chitosan - pharmacology
Chromatography, Gel - methods
Drug Evaluation, Preclinical - methods
Escherichia coli - drug effects
Escherichia coli - physiology
Mannans - chemical synthesis
Mannans - pharmacology
Plants
Tensile Strength - drug effects
Tensile Strength - physiology
X-Ray Diffraction - methods
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Summary:[Display omitted] •A two-step casting technique was used to prepare KGM/CHI bilayer films.•The bilayer films preserved the physicochemical properties of each polymer.•The two polymers presented good thermostability and miscibility.•The bilayer films exhibit low cytotoxicity and inhibit microbial penetration.•The bilayer films created a suitable moist environment for wound healing. A novel bilayer film of chitosan and konjac glucomannan were prepared by the two-step casting technique. Blend films were also prepared to investigate the interactions between the two polymers in the interfacial region of the bilayer structure. Scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction analysis showed that, unlike in the blends, the physicochemical properties of each biopolymer were preserved in the bilayer film. Differential scanning calorimetry and thermogravimetric analysis also indicated a good thermostability and miscibility for both polymers, probably due to strong hydrogen bonds between their polymer chains. Biological, mechanical and water vapor transmission tests showed a high biocompatibility, low cytotoxicity, and suitable mechanical and barrier properties of the bilayer films for wound dressing applications.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2019.02.017