Endoscopic Submucosal Dissection for Esophageal Adenocarcinoma: A North American Perspective

• Published in: Journal of gastrointestinal surgery 2019-06, Vol.23 (6), p.1087-1094
• Main Authors: Bouchard, Philippe, Molina, Juan-Carlos, Cools-Lartigue, Jonathan, Spicer, Jonathan, Mueller, Carmen L., Ferri, Lorenzo E.
• Format: Article
• Language: English
• Subjects: 2017 SSAT Plenary Presentation; Adenocarcinoma - diagnostic imaging; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Aged; Aged, 80 and over; Canada; Endoscopic Mucosal Resection - adverse effects; Endoscopy; Endosonography; Esophageal cancer; Esophageal Neoplasms - diagnostic imaging; Esophageal Neoplasms - pathology; Esophageal Neoplasms - surgery; Esophageal Perforation - etiology; Esophageal Perforation - surgery; Esophagectomy - methods; Female; Gastroenterology; Gastrointestinal surgery; Health risk assessment; Humans; Laparoscopy; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Recurrence, Local - surgery; Neoplasm, Residual; Patients; Reoperation; Salvage Therapy; Surgery; Treatment Outcome
• ISSN: 1091-255X; 1873-4626
• DOI: 10.1007/s11605-018-04093-w

Background Data are limited regarding the application of endoscopic submucosal dissection (ESD) in Western countries or for esophageal adenocarcinoma in any part of the world. We sought to review our experience employing ESD in patients with early esophageal cancer at a high volume North American esophageal cancer treatment center. Methods A prospectively maintained database of all patients with esophageal cancer treated at the McGill University Health Center was used to identify ESDs performed for adenocarcinoma between 2012 and 2016. Patient demographics, pre-resection tumor characteristics, endoscopic resection technical variables, pathologic results, and short- and long-term outcomes were recorded. Results Of 650 patients in the database, 26 underwent 27 procedures. The majority (67%) had pre-treatment EUS. There were no post-ESD bleeding events requiring re-intervention. Perforation occurred in 2/27 (7%), one of which required operative repair. Complete RO resection was achieved in 18/27(67%). Salvage laparoscopic esophagectomy was performed in six patients. At a median follow-up of 18.5 (7–35) months, cancer recurrence occurred in only one patient who subsequently underwent successful repeat ESD. Conclusions Although technically challenging, ESD represents a safe and effective treatment of early esophageal adenocarcinoma and has the potential to become a more important tool in management of these early lesions in Western countries.