A novel semiautomatic segmentation protocol to evaluate guided bone regeneration outcomes: A pilot randomized, controlled clinical trial

Objectives The aims of this study were to (a) present a novel morphological contour interpolation (MCI) algorithm based method to evaluate grafted bone alterations following guided bone regeneration (GBR), (b) compare clinical and radiological outcomes of GBR with two different collagen membranes. M...

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Bibliographic Details
Published in:Clinical oral implants research 2019-04, Vol.30 (4), p.344-352
Main Authors: Li, Yuan, Qiao, Shi‐Chong, Gu, Ying‐Xin, Zhang, Xiao‐Meng, Shi, Jun‐Yu, Lai, Hong‐Chang
Format: Article
Language:English
Subjects:
Algorithms
Bone density
Bone grafts
Bone growth
Bone surgery
Clinical trials
Collagen
Computed tomography
cone beam computed tomography
Dentistry
Dermis
Grafting
guided bone regeneration
Interpolation
Membranes
morphological contour interpolation
Patients
Randomization
Regeneration
Regeneration (physiology)
Segmentation
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Summary:Objectives The aims of this study were to (a) present a novel morphological contour interpolation (MCI) algorithm based method to evaluate grafted bone alterations following guided bone regeneration (GBR), (b) compare clinical and radiological outcomes of GBR with two different collagen membranes. Materials and methods The data were retrieved from an ongoing randomized controlled trial. Patients were randomly allocated into two groups: (a) control group (CG): Bio‐Gide (b) test group (TG): bovine dermis‐derived collagen membrane. Cone beam computed tomography examinations were performed 1 week (T0) and 6 months after surgery (T1). PES/WES at T1, grafted bone volume and density changes from T0 to T1 were recorded. Results Thirty‐six patients (16/20 in test/control group, respectively) were enrolled in the present study. Excellent inter‐observer reliability (ICC ≥ 0.97) was revealed for repeated measurements using this method. Significant volumetric reduction of grafted bone were found in both groups (test group: from 0.60 to 0.39 cm3, p 
ISSN:0905-7161
1600-0501
DOI:10.1111/clr.13420