Palladium-Catalyzed β‑C–H Arylation of Aliphatic Aldehydes and Ketones Using Amino Amide as a Transient Directing Group

This paper describes a new amino-amide-based transient directing group (TDG). The TDG can exhibit better performance in the Pd-catalyzed arylation of aliphatic aldehydes and ketones. This reaction showed good substrate compatibility and regioselectivity. The results indicated that 3-amino-N-isopropy...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2019-04, Vol.21 (7), p.2085-2089
Main Authors: Dong, Cong, Wu, Liangfei, Yao, Jianwei, Wei, Kun
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This paper describes a new amino-amide-based transient directing group (TDG). The TDG can exhibit better performance in the Pd-catalyzed arylation of aliphatic aldehydes and ketones. This reaction showed good substrate compatibility and regioselectivity. The results indicated that 3-amino-N-isopropylpropionamide was more beneficial to the β-arylation of aliphatic aldehydes than other TDGs under relatively mild conditions.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b00366