Palladium-Catalyzed β‑C–H Arylation of Aliphatic Aldehydes and Ketones Using Amino Amide as a Transient Directing Group

This paper describes a new amino-amide-based transient directing group (TDG). The TDG can exhibit better performance in the Pd-catalyzed arylation of aliphatic aldehydes and ketones. This reaction showed good substrate compatibility and regioselectivity. The results indicated that 3-amino-N-isopropy...

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Published in:Organic letters 2019-04, Vol.21 (7), p.2085-2089
Main Authors: Dong, Cong, Wu, Liangfei, Yao, Jianwei, Wei, Kun
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Language:English
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container_title Organic letters
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creator Dong, Cong
Wu, Liangfei
Yao, Jianwei
Wei, Kun
description This paper describes a new amino-amide-based transient directing group (TDG). The TDG can exhibit better performance in the Pd-catalyzed arylation of aliphatic aldehydes and ketones. This reaction showed good substrate compatibility and regioselectivity. The results indicated that 3-amino-N-isopropylpropionamide was more beneficial to the β-arylation of aliphatic aldehydes than other TDGs under relatively mild conditions.
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title Palladium-Catalyzed β‑C–H Arylation of Aliphatic Aldehydes and Ketones Using Amino Amide as a Transient Directing Group
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