A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+‑Dependent Enzymes

DNA-encoded chemical libraries are increasingly used in pharmaceutical research because they enable the rapid discovery of synthetic protein ligands. Here we explored whether target-class focused DNA-encoded chemical libraries can be cost-effective tools to achieve robust screening productivity for...

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Bibliographic Details
Published in:	Journal of the American Chemical Society 2019-04, Vol.141 (13), p.5169-5181
Main Authors:	Yuen, Lik Hang, Dana, Srikanta, Liu, Yu, Bloom, Samuel I, Thorsell, Ann-Gerd, Neri, Dario, Donato, Anthony J, Kireev, Dmitri, Schüler, Herwig, Franzini, Raphael M
Format:	Article
Language:	English
Subjects:	ADP Ribose Transferases - antagonists & inhibitors ADP Ribose Transferases - metabolism cost effectiveness DNA - chemistry Drug Discovery enzyme activity Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology enzymes Humans ligands Models, Molecular Molecular Structure proteins screening Sirtuins - antagonists & inhibitors Sirtuins - metabolism Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology
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