Correlation and agreement between the TEG 5000 and the TEG 6s during liver transplant surgery

The TEG 5000 and novel TEG 6s measure the viscoelasticity of whole blood during in vitro clot formation. The two devices measure similar coagulation variables but utilize distinctly different technologies. This study aimed to determine the correlation and agreement between the thrombelastographic pa...

Full description

Saved in:
Bibliographic Details
Published in:Anaesthesia and intensive care 2019-01, Vol.47 (1), p.32-39
Main Authors: Robson, Jacqueline L, DJ Watts, Andrew, McCulloch, Timothy J, Paleologos, Michael S, Mortimer, Ross A, Kam, Peter CA
Format: Article
Language:English
Subjects:
Agreements
Algorithms
Anesthesiology
Authorship
Blood
Blood transfusions
Clinical trials
Heart surgery
Hemostasis
Laboratories
Liver
Liver transplants
Patients
Point-of-care testing
Rheology
Surgery
Thrombelastography
Transplantation
Transplants & implants
Viscoelasticity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The TEG 5000 and novel TEG 6s measure the viscoelasticity of whole blood during in vitro clot formation. The two devices measure similar coagulation variables but utilize distinctly different technologies. This study aimed to determine the correlation and agreement between the thrombelastographic parameters obtained by the two devices during liver transplant surgery. We obtained blood samples at six predefined intervals during the surgery of 10 consecutive patients. Two operators proficient in the use of the TEG 6s and TEG 5000 systems performed thrombelastographic measurements on each sample: non-citrated TEG 5000, citrated TEG 5000 and citrated TEG 6s. Agreement and correlation were assessed using Bland Altman plots and Lin's concordance correlation. There was considerable inter-device variability for the different parameters measured by the TEG 5000 and TEG 6s devices. Acceptable agreement was observed when results were within the normal reference ranges. However, with increasing coagulopathy, agreement was poor and results could not be considered interchangeable. Although each of the three tests appeared reliable for qualitative detection of abnormalities of clot formation during liver transplant surgery, we found their quantitative results were not interchangeable.
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057X18811731