Neurochemical insights into the radiation protection of astronauts: Distinction between low- and moderate-LET radiation components

• Published in: Physica medica 2019-01, Vol.57, p.7-16
• Main Authors: Belov, Oleg V., Belokopytova, Ksenia V., Kudrin, Vladimir S., Molokanov, Aleksandr G., Shtemberg, Andrey S., Bazyan, Ara S.
• Format: Article
• Language: English
• Subjects: Carbon ions; Central nervous system; Protons; Radiation protection; Space radiation
• ISSN: 1120-1797; 1724-191X
• DOI: 10.1016/j.ejmp.2018.12.003

[Display omitted] •New insights are gained into radiation damage to the central nervous system.•Neurochemical outcomes of exposure to protons or 12C ions are comparatively studied.•Brain regions differ in their responses to proton or 12C ion exposures.•12C ions induce overall metabolic changes while protons cause only particular ones.•There is a time shift between neurochemical profiles formed by protons and 12C ions. Radiation protection of astronauts remains an ongoing challenge in preparation of deep space exploratory missions. Exposure to space radiation consisting of multiple radiation components is associated with a significant risk of experiencing central nervous system (CNS) detriments, potentially influencing the crew operational decisions. Developing of countermeasures protecting CNS from the deleterious exposure requires understanding the mechanistic nature of cognitive impairments induced by different components of space radiation. The current study was designed to identify differences in neurochemical modifications caused by exposure to low- and moderate-LET radiations and to elucidate a distinction between the observed outcomes. We exposed rats to accelerated protons (170 MeV; 0.5 keV/μm) or to carbon ions (12C; 500 MeV/u; 10.5 keV/μm) delivered at the same dose of 1 Gy. Neurochemical alterations were evaluated 1, 30, and 90 days after exposure via indices of the monoamine metabolism measured in five brain structures, including prefrontal cortex, hypothalamus, nucleus accumbens, hippocampus and striatum. We obtained the detailed patterns of neurochemical modifications after exposure to the mentioned radiation modalities. Our data show that the enhancement in the radiation LET from relatively low to moderate values leads to different neurochemical outcomes and that a particular effect depends on the irradiated brain structure. We also hypothesized that exposure to the moderate-LET radiations can induce a hyperactivation of feedback neurochemical mechanisms, which blur metabolic deviations and lead to the delayed impairments in brain functions. Based on our findings we discuss possible contribution of the observed changes to behavioural impairments.