Abnormal synchronization patterns in the electrical stimulation-contractile response coupling decrease with noise

Synchronization theory predicts that if an oscillator interacts with a rhythmical external force, then it should react to a rhythmical force by adjusting its frequency. Furthermore, noise is present in nature, and it affects the nervous and cardiovascular systems. In this paper, we analyze the heart...

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Bibliographic Details
Published in:BioSystems 2019-06, Vol.180, p.63-70
Main Authors: Peña-Romo, Alberto, Ríos, Amelia, Escalante, Bruno A., Rodríguez-González, Jesús
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Additive Gaussian noise
Animals
Computer Simulation
Electric Stimulation
Frequency-locking
Heart - physiology
Heart Rate - physiology
High-order modes
Isolated Heart Preparation
Male
Mice
Models, Cardiovascular
Myocardial Contraction - physiology
Noise
Nonlinear oscillator
Systems biology
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Summary:Synchronization theory predicts that if an oscillator interacts with a rhythmical external force, then it should react to a rhythmical force by adjusting its frequency. Furthermore, noise is present in nature, and it affects the nervous and cardiovascular systems. In this paper, we analyze the heart as an oscillator, where noisy periodic electrical stimulation can be regarded as an external forcing. This study aimed to investigate, from an experimental point of view, whether noise can induce synchronization of higher order in the mechanical heart response. A Langendorff heart preparation was used to obtain two variables of the mechanical response, intensity of contractile force and heart rate. The experiments show frequency locking in the electrical stimulation-contractile response coupling with and without noise induced. The role of noise in the response of effector organs invites further investigation.
ISSN:0303-2647
1872-8324
DOI:10.1016/j.biosystems.2019.03.004