The degree of hepatic steatosis associates with impaired cardiac and autonomic function

[Display omitted] •Patients with elevated liver fat and poor metabolic control have impaired cardiac and autonomic function.•Liver fat, metabolic dysfunction, inflammation and fibrosis staging correlate with cardiac and autonomic dysfunction.•Elevated alcohol intake enhanced the impact of liver fat...

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Bibliographic Details
Published in:Journal of hepatology 2019-06, Vol.70 (6), p.1203-1213
Main Authors: Houghton, David, Zalewski, Paweł, Hallsworth, Kate, Cassidy, Sophie, Thoma, Christian, Avery, Leah, Slomko, Joanna, Hardy, Timothy, Burt, Alastair D., Tiniakos, Dina, Hollingsworth, Kieren G., Taylor, Roy, Day, Christopher P., Masson, Steven, McPherson, Stuart, Anstee, Quentin M., Newton, Julia L., Trenell, Michael I.
Format: Article
Language:English
Subjects:
Adult
Aged
Alcohol
Alcoholic beverages
Autonomic
Autonomic nervous system
Autonomic Nervous System - physiopathology
Blood pressure
Cardiac
Cardiovascular diseases
Cardiovascular Diseases - etiology
Fatty liver
Fatty Liver - complications
Fatty Liver - physiopathology
Female
Fibrosis
Heart - physiopathology
Hemodynamics - physiology
Humans
Inflammation
Liver diseases
Liver fat
Magnetic resonance spectroscopy
Male
Metabolic disorders
Metabolism
Middle Aged
Morbidity
Non-alcoholic Fatty Liver Disease - physiopathology
Risk factors
Steatosis
Tumor necrosis factor-α
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Summary:[Display omitted] •Patients with elevated liver fat and poor metabolic control have impaired cardiac and autonomic function.•Liver fat, metabolic dysfunction, inflammation and fibrosis staging correlate with cardiac and autonomic dysfunction.•Elevated alcohol intake enhanced the impact of liver fat on diastolic autonomic dysfunction. Cardiovascular disease is the principle cause of death in patients with elevated liver fat unrelated to alcohol consumption, more so than liver-related morbidity and mortality. The aim of this study was to evaluate the relationship between liver fat and cardiac and autonomic function, as well as to assess how impairment in cardiac and autonomic function is influenced by metabolic risk factors. Cardiovascular and autonomic function were assessed in 96 sedentary individuals: i) non-alcoholic fatty liver disease (NAFLD) (n = 46, hepatic steatosis >5% by magnetic resonance spectroscopy), ii) Hepatic steatosis and alcohol (dual aetiology fatty liver disease [DAFLD]) (n = 16, hepatic steatosis >5%, consuming >20 g/day of alcohol) and iii) CONTROL (n = 34, no cardiac, liver or metabolic disorders,
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2019.01.035