Cerebrolysin improves peripheral inflammatory pain: Sex differences in two models of acute and chronic mechanical hypersensitivity

Chronic inflammatory pain is a major health problem worldwide with high prevalence in women. Cerebrolysin is a multimodal neuropeptide preparation that crosses the blood brain barrier and displays neuroprotective properties in aging and disease. Previously, we showed that cerebrolysin reduced mechan...

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Bibliographic Details
Published in:Drug development research 2019-06, Vol.80 (4), p.513-518
Main Authors: Morales‐Medina, Julio C., Flores, Gonzalo, Vallelunga, Annamaria, Griffiths, Natalie H., Iannitti, Tommaso
Format: Article
Language:English
Subjects:
Acute Pain - drug therapy
Acute Pain - immunology
Aging
allodynia
Amino Acids - therapeutic use
Animals
Blood-brain barrier
Brain
Carrageenan
cerebrolysin
CFA
Chronic Pain - drug therapy
Chronic Pain - immunology
Disease Models, Animal
Edema
Edema - drug therapy
Edema - immunology
Female
Freund's Adjuvant
Gender aspects
Gender differences
Hyperalgesia - drug therapy
Hyperalgesia - immunology
Hypersensitivity
Inflammation
Male
neuropeptide
Neuroprotection
Neuroprotective Agents - therapeutic use
Pain
Pain Measurement
Pain perception
peripheral inflammation
peripheral pain
Rats, Wistar
Sex
Sex Characteristics
Sex differences
Time Factors
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Summary:Chronic inflammatory pain is a major health problem worldwide with high prevalence in women. Cerebrolysin is a multimodal neuropeptide preparation that crosses the blood brain barrier and displays neuroprotective properties in aging and disease. Previously, we showed that cerebrolysin reduced mechanical allodynia in a model of persistent inflammation and pain. We aim to build upon the findings of our previous study by investigating the response to acute administration of cerebrolysin in two models of peripheral inflammation and assessing sex differences. We utilized the complete Freund's adjuvant (CFA) that produces maximal oedema and mechanical allodynia within days and carrageenan that produces similar effects within hours. Cerebrolysin reversed the mechanical allodynia in both sexes in CFA‐treated rats. On the other hand, in rats treated with carrageenan, cerebrolysin was only effective in reducing mechanical allodynia in female rats. In conclusion, the present study shows that cerebrolysin effects may be sex‐specific depending on different mechanisms that are at play in these two models of peripheral inflammatory pain. Further investigations are required to determine the factors contributing to sex differences.
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.21528