NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in intracellular and systemic iron homeostasis. Disruptions in iron homeostasis and autophagy are observed in several neurode...

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Bibliographic Details
Published in:Frontiers in neuroscience 2019-03, Vol.13, p.238
Main Authors: Quiles Del Rey, Maria, Mancias, Joseph D
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Bioavailability
Disease
Erythropoiesis
Ferritin
ferritinophagy
ferroptosis
Homeostasis
Iron
iron homeostasis
Mass spectrometry
Metabolism
Molecular modelling
NCOA4
Neurodegeneration
neurodegenerative disease
Neurodegenerative diseases
neurodegenerative disorders
Neuroscience
Oxidative stress
Phagocytosis
Scientific imaging
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