Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis

The histone demethylase KDM6B (JMJD3) is upregulated in blood disorders, suggesting that it may have important pathogenic functions. Here we examined the function of Kdm6b in hematopoietic stem cells (HSC) to evaluate its potential as a therapeutic target. Loss of Kdm6b lead to depletion of phenotyp...

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Bibliographic Details
Published in:Leukemia 2019-10, Vol.33 (10), p.2506-2521
Main Authors: Mallaney, Cates, Ostrander, Elizabeth L., Celik, Hamza, Kramer, Ashley C., Martens, Andrew, Kothari, Alok, Koh, Won Kyun, Haussler, Emily, Iwamori, Naoki, Gontarz, Paul, Zhang, Bo, Challen, Grant A.
Format: Article
Language:English
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Activator protein 1
Acute lymphoblastic leukemia
Acute myeloid leukemia
Animals
Blood cancer
Cancer Research
Carcinogenesis - metabolism
Carcinogenesis - pathology
Cell Differentiation - genetics
Cell Self Renewal - genetics
Cell Self Renewal - physiology
Cell self-renewal
Cellular stress response
Chromatin
Critical Care Medicine
Depletion
Fetuses
Gene expression
Genetic aspects
Growth
Health aspects
Hematology
Hematopoietic stem cells
Hematopoietic Stem Cells - metabolism
Hematopoietic Stem Cells - pathology
Histones
Inflammation
Intensive
Internal Medicine
Jumonji Domain-Containing Histone Demethylases - metabolism
Leukemia
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - pathology
Leukemogenesis
Leukocytes
Lymphocytes T
Medicine
Medicine & Public Health
Mice
Mice, Inbred C57BL
Myeloid leukemia
Oncology
Stem cell transplantation
Stem cells
T-Lymphocytes - pathology
Therapeutic applications
Transcription factors
Transcription Factors - genetics
Up-Regulation - genetics
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