Seasonal influenza vaccines induced high levels of neutralizing cross-reactive antibody responses against different genetic group influenza A(H1N1)pdm09 viruses

•Antibody titers of the HI and MN assays correlated strongly positively.•A HI titer of 40 was considered to be equivalent to a MN titer of 160.•(day 21) GMTs were higher in the Fluarix group as compared to the Vaxigrip group.•Pre-existing SR values were higher in 2012 compared to those seen in the 2...

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Bibliographic Details
Published in:Vaccine 2019-05, Vol.37 (20), p.2731-2740
Main Authors: Haveri, Anu, Ikonen, Niina, Kantele, Anu, Anttila, Veli-Jukka, Ruotsalainen, Eeva, Savolainen-Kopra, Carita, Julkunen, Ilkka
Format: Article
Language:English
Subjects:
Amino acids
Antibodies
Antigens
Epidemics
Hemagglutination inhibition
Humoral immunity
Immunity
Influenza
Influenza A
Medical personnel
Microneutralization test
Neutralizing
Pandemic
Pandemics
Phylogenetics
Strains (organisms)
Studies
Vaccine
Vaccines
Viruses
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Summary:•Antibody titers of the HI and MN assays correlated strongly positively.•A HI titer of 40 was considered to be equivalent to a MN titer of 160.•(day 21) GMTs were higher in the Fluarix group as compared to the Vaxigrip group.•Pre-existing SR values were higher in 2012 compared to those seen in the 2010.•Both vaccinations induced very high SRs. Influenza A(H1N1)pdm09 viruses have been circulating throughout the world since the 2009 pandemic. A/California/07/2009 (H1N1) virus was included in seasonal influenza vaccines for seven years altogether, providing a great opportunity to analyse vaccine-induced immunity in relation to the postpandemic evolution of the A(H1N1)pdm09 virus. Serum antibodies against various epidemic strains of influenza A(H1N1)pdm09 viruses were measured among health care workers (HCWs) by haemagglutination inhibition and microneutralization tests before and after 2010 and 2012 seasonal influenza vaccinations. We detected high responses of vaccine-induced neutralizing antibodies to six distinct genetic groups. Our results indicate antigenic similarity between vaccine and circulating A(H1N1)pdm09 strains, and substantial vaccine-induced immunity against circulating epidemic viruses.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2019.03.078