Ultra-high-resolution ion mobility spectrometry—current instrumentation, limitations, and future developments

With recent advances in ionization sources and instrumentation, ion mobility spectrometers (IMS) have transformed from a detector for chemical warfare agents and explosives to a widely used tool in analytical and bioanalytical applications. This increasing measurement task complexity requires higher...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2019-09, Vol.411 (24), p.6229-6246
Main Authors: Kirk, Ansgar T., Bohnhorst, Alexander, Raddatz, Christian-Robert, Allers, Maria, Zimmermann, Stefan
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Biological & chemical weapons
Characterization and Evaluation of Materials
Chemical warfare
Chemical warfare agents
Chemistry
Chemistry and Materials Science
Close-Up of Current Developments in Ion Mobility Spectrometry
Drift tubes
Explosives detection
Food Science
High resolution
Instrumentation
Instruments
Ionic mobility
Ionization
Ions
Laboratory Medicine
Methamphetamine
Mobility
Monitoring/Environmental Analysis
Organic chemistry
Resolution
Review
Spectrometers
Spectrometry
Task complexity
Traveling waves
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Summary:With recent advances in ionization sources and instrumentation, ion mobility spectrometers (IMS) have transformed from a detector for chemical warfare agents and explosives to a widely used tool in analytical and bioanalytical applications. This increasing measurement task complexity requires higher and higher analytical performance and especially ultra-high resolution. In this review, we will discuss the currently used ion mobility spectrometers able to reach such ultra-high resolution, defined here as a resolving power greater than 200. These instruments are drift tube IMS, traveling wave IMS, trapped IMS, and field asymmetric or differential IMS. The basic operating principles and the resulting effects of experimental parameters on resolving power are explained and compared between the different instruments. This allows understanding the current limitations of resolving power and how ion mobility spectrometers may progress in the future. Graphical abstract
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-019-01807-0