ROS-responsive targeting micelles for optical imaging-guided chemo-phototherapy of cancer

[Display omitted] •Paclitaxel as hydrophobic segments of amphiphilic polymers was developed.•A hydrogen peroxide (H2O2)-responsive bond was introduced in the copolymer.•PTX was encapsulated into multifunctional micelles for targeted drug delivery.•A NIR dye as both a photosensitizer and photothermal...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-07, Vol.179, p.218-225
Main Authors: Li, Xiaodan, Zhang, Chuan, Zheng, Qianqian, Shi, Xiaoju
Format: Article
Language:English
Subjects:
Cancer therapy
Chemo-phototherapy
Imaging-guided therapy
Paclitaxel
ROS-responsive
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Summary:[Display omitted] •Paclitaxel as hydrophobic segments of amphiphilic polymers was developed.•A hydrogen peroxide (H2O2)-responsive bond was introduced in the copolymer.•PTX was encapsulated into multifunctional micelles for targeted drug delivery.•A NIR dye as both a photosensitizer and photothermal agent was introduced. The combination of chemotherapy and phototherapy gives rise to a boom in cancer therapy methodology. An all-in-one nanoplatform is of particular interest for increased safety and efficacy geared toward personalized precision medicine. However, low drug loading efficiency, random dispersion and distribution without visualization are widespread concerns. Here, a reactive oxygen species (ROS) responsive drug delivery system for imaging-guided chemo-phototherapy was developed. Polymeric micelles were designed and synthesized using PTX (drug) and Cypate (fluorescence and photosensitizer) as hydrophobic segments and PEG as hydrophilic ones encapsulating PTX. Furthermore, folic acid, as a targeting moiety, was conjugated to PEG for directed drug delivery. We evaluated the ROS-responsive drug release profiles and chemo-phototherapy application in an anticancer therapy. The results suggest these biocompatible amphiphilic polymer conjugates would be promising for applications in imaging-guided chemo-phototherapy.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2019.04.005