When Failure Is Worse Than Giving Up: The Case of CTL

Although much emphasis is given to the use of immune checkpoint inhibitors to restore the functionality of exhausted lymphocytes, very little is known about the fate of cancer cells that escape from the cytotoxic activity of T cells. In a previous issue of , Stein and colleagues investigated the res...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2019-04, Vol.79 (8), p.1753-1755
Main Authors: Colombo, Mario Paolo, Lecis, Daniele
Format: Article
Language:English
Subjects:
Breast Neoplasms
CD8-Positive T-Lymphocytes - immunology
Cytotoxicity, Immunologic - immunology
Humans
Neoplastic Stem Cells
T-Lymphocytes, Cytotoxic - immunology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although much emphasis is given to the use of immune checkpoint inhibitors to restore the functionality of exhausted lymphocytes, very little is known about the fate of cancer cells that escape from the cytotoxic activity of T cells. In a previous issue of , Stein and colleagues investigated the response of cancer cells to CD8 T cells disarmed of their killing activity. Spared cancer cells acquired stem cell-like features and displayed an enhanced capacity to form tumors and metastasize. These increased tumorigenic properties could represent the other side of the coin of T-cell surveillance seen in wound healing in which recognition of damaged tissue as "self" gives the green light for healing process. .
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-19-0690