Coronary microvascular dysfunction is associated with cardiac time intervals in women with angina and no obstructive coronary artery disease: An iPOWER substudy

Background Coronary microvascular dysfunction (CMD) may cause angina in the absence of obstructive coronary artery disease (CAD) and increases the risk of future adverse cardiovascular events. Transthoracic Doppler echocardiography (TTDE) with pharmacological stress can assess coronary flow velocity...

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Published in:Echocardiography (Mount Kisco, N.Y.) N.Y.), 2019-06, Vol.36 (6), p.1110-1117
Main Authors: Pena, Adam, Michelsen, Marie Mide, Mygind, Naja Dam, Gustafsson, Ida, Høst, Nis, Bech, Jan, Kastrup, Jens, Hansen, Henrik Steen, Hansen, Peter Riis, Prescott, Eva
Format: Article
Language:English
Subjects:
Angina Pectoris - etiology
Angina Pectoris - physiopathology
Blood Flow Velocity
Cohort Studies
Coronary Artery Disease
Coronary Circulation
coronary flow reserve
Coronary Thrombosis - complications
Coronary Thrombosis - diagnostic imaging
Coronary Thrombosis - physiopathology
Echocardiography, Doppler - methods
Echocardiography, Stress
Female
Humans
Microcirculation - physiology
Middle Aged
myocardial performance index
Prospective Studies
Time Factors
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Summary:Background Coronary microvascular dysfunction (CMD) may cause angina in the absence of obstructive coronary artery disease (CAD) and increases the risk of future adverse cardiovascular events. Transthoracic Doppler echocardiography (TTDE) with pharmacological stress can assess coronary flow velocity reserve (CFVR), a measure of coronary microvascular function. However, simpler methods would be preferable for diagnosing CMD. Therefore, we examined the relationship between CFVR and cardiac time intervals measured by TTDE in a cohort of women with angina and no obstructive CAD. Methods In a prospective cohort study, we included 389 women with angina, left ventricular ejection fraction > 45%, and no obstructive CAD. CMD was defined as CFVR 
ISSN:0742-2822
1540-8175
DOI:10.1111/echo.14356