A sensitive ratiometric fluorescent probe for quantitive detection and imaging of alkaline phosphatase in living cells

We report a sensitive fluorescence probe Ratio-ALP for in vivo ratiometric imaging of alkaline phosphatase (ALP). The probe was designed by conjugating a naphthalimide with a phosphate group as the responsive moiety for enzymatic reactions. The fluorescence intensity ratio displayed a linear relatio...

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Bibliographic Details
Published in:Analytica chimica acta 2019-08, Vol.1066, p.131-135
Main Authors: Gao, Congcong, Zang, Shunping, Nie, Longxue, Tian, Yong, Zhang, Rubo, Jing, Jing, Zhang, Xiaoling
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Biocompatibility
Cell permeability
Cells (biology)
Cytotoxicity
Fluorescence
Fluorescent indicators
Fluorescent probe
Phosphatase
Ratiometric
Selectivity
Toxicity
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