Widespread Pressure Pain Hyperalgesia Is Not Related to Pain in Patients with Parkinson’s Disease

Abstract Objective Pain is one of the most frequent nonmotor impairments in Parkinson’s disease (PD) and is hypothesized to be associated with altered nociceptive pain processing. Our aims were to investigate differences in widespread pressure pain sensitivity between PD patients with and without pa...

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Published in:Pain medicine (Malden, Mass.) Mass.), 2020-02, Vol.21 (2), p.232-238
Main Authors: Ferreira-Sánchez, María R, Moreno-Verdú, Marcos, Cano-de-la-Cuerda, Roberto, Fernández-de-las-Peñas, César, Güeita-Rodríguez, Javier, Ortega-Santiago, Ricardo
Format: Article
Language:English
Subjects:
Aged
Dopamine
Female
Health aspects
Humans
Hyperalgesia
Hyperalgesia - etiology
Male
Metacarpal
Middle Aged
Movement disorders
Neurodegenerative diseases
Nociceptive Pain - etiology
Pain
Pain management
Pain perception
Pain Threshold - physiology
Parkinson Disease - complications
Parkinson's disease
Physiological aspects
Pressure
Quality of life
Sex differences
Skeletal muscle
Sleep
Spine (cervical)
Tibialis anterior muscle
Touch
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Summary:Abstract Objective Pain is one of the most frequent nonmotor impairments in Parkinson’s disease (PD) and is hypothesized to be associated with altered nociceptive pain processing. Our aims were to investigate differences in widespread pressure pain sensitivity between PD patients with and without pain and healthy controls and to assess the relationship of health-related quality of life and sleep quality with pressure pain sensitivity. Methods Nineteen PD patients with pain (12 men, age = 68 ± 9 years), 19 PD patients without pain (11 men, age = 69 ± 8 years), and 19 matched controls participated. Pressure pain thresholds (PPTs) were assessed bilaterally over the cervical spine, the second metacarpal, and the tibialis anterior by an assessor blinded to the subject’s condition. Patients were assessed in a dopamine-medicated (ON) state. Pain intensity (numerical pain rating scale, 0–10), health-related quality of life (39-item Parkinson’s Disease Questionnaire), and sleep quality (Pittsburgh Sleep Quality Index) were also assessed. Results No significant differences existed between PD patients, with or without pain, and healthy controls on PPTs over the cervical spine, the second metacarpal, or the tibialis anterior muscle (all P > 0.3). PPTs were lower in females than in males in all groups (P 
ISSN:1526-2375
1526-4637
DOI:10.1093/pm/pnz091