Association of serum uric acid levels with the incident of kidney disease and rapid eGFR decline in Chinese individuals with eGFR > 60 mL/min/1.73 m2 and negative proteinuria

• Published in: Clinical and experimental nephrology 2019-07, Vol.23 (7), p.871-879
• Main Authors: Zhou, Fangfang, Yu, Geping, Wang, Guoyu, Liu, Yunzi, Zhang, Liwen, Wang, Weiming, Chen, Nan
• Format: Article
• Language: English
• Subjects: Creatinine; Epidermal growth factor receptors; Glomerular filtration rate; Hematocrit; Hemoglobin; Hyperlipidemia; Kidney diseases; Medicine; Medicine & Public Health; Nephrology; Proteinuria; Review Article; Risk factors; Uric acid; Urology
• ISSN: 1342-1751; 1437-7799
• DOI: 10.1007/s10157-019-01705-w

Background Epidemiological studies suggest that higher serum uric acid (SUA) level is significantly associated with kidney disease development. However, it remains debatable whether higher SUA is independently associated with new-onset kidney disease and rapid eGFR decline in individuals with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m 2 and negative proteinuria. Methods This was a large, single-center, retrospective 6-year cohort study at People’s Hospital of Tonglu County, Zhejiang, from 2001 to 2006. We enrolled 10,677 participants (19–92 years) with eGFR ≥ 60 mL/min/1.73 m 2 and without dipstick proteinuria at baseline. The association between SUA change and the occurrence of renal outcomes and annual eGFR decline were evaluated using Cox models with adjustment for confounders. Results Higher quartiles (2.51%) of SUA levels were associated with greater prevalence of kidney disease compared with quartile 1 (0.52%), 2 (1.13%) and 3 (1.76%), respectively. In addition, greater baseline SUA levels [OR (95% CI) 3.29(1.68–6.45), p