Toward understanding the causes of blood pH irregularities and the roles of newly described binuclear neurons of carotid bodies on blood pH regulation during subarachnoid hemorrhage: Experimental study

Acidosis is the most dangerous complication of subarachnoid hemorrhage (SAH). Although the carotid bodies (CBs) network is essential for pH regulation, neither binuclear neurons (BNN) nor their functions have been mentioned so far in the literature. The aim of this study was to investigate the cruci...

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Bibliographic Details
Published in:Neuropathology 2019-08, Vol.39 (4), p.259-267
Main Authors: Ozmen, Sevilay, Altinkaynak, Konca, Aydin, Mehmet D., Ahiskalioglu, Ali, Demirci, Tuba, Özlü, Can, Kanat, Ayhan, Aydin, Nazan
Format: Article
Language:English
Subjects:
Acidosis
Acidosis - complications
Aneurysms
Animals
binuclear neuron
Blood
carotid body
Carotid Body - metabolism
Carotid Body - pathology
Degeneration
glossopharyngeal nerve
Hydrogen-Ion Concentration
Neurons - metabolism
Neurons - pathology
pH effects
Rabbits
Subarachnoid hemorrhage
Subarachnoid Hemorrhage - blood
Subarachnoid Hemorrhage - complications
Subarachnoid Hemorrhage - pathology
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Summary:Acidosis is the most dangerous complication of subarachnoid hemorrhage (SAH). Although the carotid bodies (CBs) network is essential for pH regulation, neither binuclear neurons (BNN) nor their functions have been mentioned so far in the literature. The aim of this study was to investigate the crucial roles of mononuclear (MNN) or BNN in CBs on acidosis following SAH. Twenty‐five hybrid rabbits were used. Five rabbits were used as a control group, six for sham, and the remaining 14 rabbits were used as the study group by injection of 1 mL of autologous arterial blood into the cisterna magna to produce SAH. Normal and degenerated MNN/BNN densities of CBs were counted by stereological methods. The mean blood pH values were: 7.362 ± 0.041 in the control group; 7.324 ± 0.064 in sham, 7.272 ± 0.062 in the SAH group. The degenerated MNN and BNN values were 5 ± 1/mm3 and 9 ± 3/mm3 in the control group; 15 ± 5/mm3 and 22 ± 6/mm3 in sham, 965 ± 113/mm3 and 1532 ± 176/mm3 in the SAH group. Mean pH values were under 7.212 ± 0.130 in animals with prominent degenerated BNN. The differences between MNN/pH changes were significant between the SAH and control groups (P
ISSN:0919-6544
1440-1789
DOI:10.1111/neup.12552