Myasthenia gravis and pregnancy: retrospective evaluation of 27 pregnancies in a tertiary center and comparison with previous studies

Background and aim To share our experience with the management of pregnancies in women with myasthenia gravis (MG) in a tertiary center. Methods The study retrospectively evaluated 27 pregnancies in 12 patients. The pregnancies were divided into 3 groups on the basis of the clinical course of MG dur...

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Bibliographic Details
Published in:Irish journal of medical science 2019-11, Vol.188 (4), p.1261-1267
Main Authors: Tanacan, Atakan, Fadiloglu, Erdem, Ozten, Gonca, Gunes, Ali Can, Orgul, Gokcen, Beksac, Mehmet Sinan
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - epidemiology
Adult
Birth Weight
Cesarean Section - statistics & numerical data
Family Medicine
Female
Fetal Membranes, Premature Rupture - epidemiology
General Practice
Gestational Age
Humans
Infant, Newborn
Internal Medicine
Medicine
Medicine & Public Health
Myasthenia Gravis - epidemiology
Original Article
Pregnancy
Pregnancy Complications - epidemiology
Pregnancy Outcome
Premature Birth - epidemiology
Retrospective Studies
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Summary:Background and aim To share our experience with the management of pregnancies in women with myasthenia gravis (MG) in a tertiary center. Methods The study retrospectively evaluated 27 pregnancies in 12 patients. The pregnancies were divided into 3 groups on the basis of the clinical course of MG during pregnancy: improvement ( n  = 7), disease-stable ( n  = 9), and deterioration ( n  = 11). The groups were compared with respect to patient characteristics, clinical features, and obstetric outcomes. Results There were 4 miscarriages (14.8%), 3 preterm births (11.1%), and 4 cases of preterm premature rupture of the membranes (PPROM) (14.8%). Exacerbation was observed in 25.9% of the cases; the remission rate during the postpartum period and after miscarriage was 37%. The cesarean section (CS) rate was 78.3%. Pregnancies with deterioration of MG were statistically more likely to have higher miscarriage, preterm birth, PPROM, CS, and transient neonatal MG rates, in addition to a lower gestational age at birth, birth weight, and 5-min Apgar score than pregnancies with improved or stable disease ( p values
ISSN:0021-1265
1863-4362
DOI:10.1007/s11845-019-02029-0