Sitagliptin’s effects on bone tissue and osseointegration in diabetic rats

• Published in: Archives of oral biology 2019-06, Vol.102, p.238-243
• Main Authors: Bautista, Cristhian Reynaldo Gomez, Santos, Ingrid Valadares dos, Moraes, Renata Mendonça, Chiba, Fernando Yamamoto, Sumida, Doris Hissako, Moraes, Michele Bianchi de, Vasconcellos, Luana Marotta Reis de, Anbinder, Ana Lia
• Format: Article
• Language: English
• Subjects: Animals; Bone and Bones; Dental Implants; Dentistry; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl peptidase 4; Implants; Incretins; Male; Osseointegration; Rats; Rats, Wistar; Sitagliptin Phosphate
• ISSN: 0003-9969; 1879-1506
• DOI: 10.1016/j.archoralbio.2019.04.018

•Type I diabetes has a deleterious effect on bone microarchitecture.•Type I diabetes has a deleterious effect on implant osseointegration.•Sitagliptin had no direct action on bone osseointegration or on bone remodeling. Objective: To investigate the effects of sitagliptin, a dipeptidyl peptidase 4 inhibitor used to treat type II diabetes, on bone tissue and on implant osseointegration in diabetic rats. Design: Thirty-two male rats were divided into four groups: 1) Diabetic animals (GD); 2) Diabetic animals that received sitagliptin (GDS); 3) Normoglycemic animals (GN); and 4) Normoglycemic animals that received sitagliptin (GNS). All animals received titanium implants in the right tibia. Sitagliptin or water were administered for 4 weeks. Glycemia, HOMA-IR, insulinemia, microtomographic parameters of the left tibia and implant bone area fraction occupancy (BAFO) of the right tibia were evaluated. Results: The model used to induce diabetes led to hyperglycemia. However, HOMA-IR results showed no insulin resistance, and insulinemia was lower in diabetic animals, demonstrating the development of type I diabetes. Sitagliptin administration did not influence glycemic control. The diabetic animals showed a lower BAFO and bone volume fraction, as well as a lower trabecular number and thickness, revealing the deleterious effect of diabetes on bone metabolism and osseointegration. Conclusion: In this model, sitagliptin administration did not reverse the negative effects of type I diabetes on bone, suggesting that sitagliptin has no direct action on bone tissue and has no protective bone action in decompensated diabetic animals.