Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer

Ovarian cancer (OC) is the 5th most common cancer among European women. Approximately 70-80% of OC is diagnosed at advanced stage resulting in an elevated mortality rate. The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial o...

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Bibliographic Details
Published in:Anticancer research 2019-05, Vol.39 (5), p.2475-2482
Main Authors: Christensen, Maria V, Høgdall, Claus, Jensen, Steffen G, Lokman, Noor, Ricciardelli, Carmela, Christensen, Ib J, Christiansen, Pernille, Brask, Julie, Karlsen, Mona A, Nissen, Therese K, Jochumsen, Kirsten M, Høgdall, Estrid
Format: Article
Language:English
Subjects:
Aged
Annexin A2 - genetics
Biomarkers, Tumor - genetics
Carcinoma, Ovarian Epithelial - genetics
Carcinoma, Ovarian Epithelial - pathology
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Middle Aged
Prognosis
S100 Proteins - genetics
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Summary:Ovarian cancer (OC) is the 5th most common cancer among European women. Approximately 70-80% of OC is diagnosed at advanced stage resulting in an elevated mortality rate. The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). Expression of Annexin A2 and S100A10 was evaluated in EOC tissue samples (n=303) by immunohistochemistry. The staining of the membrane, cytoplasmic and stroma was assessed according to intensity. The expression of both markers correlated to histological subtype, histological grading, International Federation of Gynecology and Obstetrics (FIGO) stage, and macro-radical surgery. Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). Multivariate Cox regression analysis demonstrated no independent prognostic significance of stromal Annexin A2 expression. High expression of Annexin A2 and S100A10 in stromal tissue from EOC patients was associated with reduced OS; however, no independent prognostic value was found for any of the markers.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13367