Hyperthermia Suppresses Post - In Vitro Proliferation and Tumor Growth in Murine Malignant Melanoma and Colon Carcinoma

Several studies have highlighted hyperthermia's ability to enhance the effectiveness of radiation and chemotherapy in various in vitro and in vivo cancer models. In vivo murine models of malignant melanoma and colon carcinoma were utilized for demonstrating hyperthermia's therapeutic effec...

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Bibliographic Details
Published in:Anticancer research 2019-05, Vol.39 (5), p.2307-2315
Main Authors: Mantso, Theodora, Vasileiadis, Stavros, Lampri, Evangeli, Botaitis, Sotiris, Perente, Sebachedin, Simopoulos, Constantinos, Chlichlia, Katerina, Pappa, Aglaia, Panayiotidis, Mihalis I
Format: Article
Language:English
Subjects:
Animals
Apoptosis - radiation effects
Carcinoma - pathology
Carcinoma - therapy
Caspase 3 - genetics
Cell Line, Tumor
Cell Proliferation - genetics
Colonic Neoplasms - pathology
Colonic Neoplasms - therapy
Cyclooxygenase 2 - genetics
Disease Models, Animal
DNA Damage - genetics
Gene Expression Regulation, Neoplastic - genetics
Histones - genetics
Humans
Hyperthermia, Induced
Melanoma - pathology
Melanoma - therapy
Melanoma, Experimental - genetics
Melanoma, Experimental - therapy
Mice
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Summary:Several studies have highlighted hyperthermia's ability to enhance the effectiveness of radiation and chemotherapy in various in vitro and in vivo cancer models. In vivo murine models of malignant melanoma and colon carcinoma were utilized for demonstrating hyperthermia's therapeutic effectiveness by examining levels of caspase 3, COX-2 and phospho-H2A.X (Ser139) as endpoints of apoptosis, proliferation and DNA damage respectively. Hyperthermia induced in vitro cytotoxicity in malignant melanoma (B16-F10) and colon carcinoma (CT26) cell lines. In addition, it reduced post-in vitro proliferation and suppression of tumor growth by inducing the expression of caspase-3 and phospho-H2A.X (Ser139) while reducing the expression of COX-2 in both murine cancer models. Hyperthermia can exert therapeutic effectiveness against melanoma and colon carcinoma by inhibiting a number of critical cellular cascades including apoptosis, proliferation and DNA damage.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13347