Circulating endothelial cells in severe Plasmodium falciparum infection

Plasmodium falciparum infection is associated with diffuse vascular dys-regulation. Levels of blood circulating endothelial cells (CECs; CD146+CD45−) are a marker of vascular injury. This study aimed to measure blood CECs by flow cytometery in patients with acute malaria infection before and after t...

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Bibliographic Details
Published in:Parasitology international 2019-10, Vol.72, p.101926-101926, Article 101926
Main Authors: El-Aswad, Bahaa El-Deen W., Sonbol, Ahmed A., Moharm, Ismail M., El-Refai, Samar A., Seleem, Hosam El-Din M., Soliman, Shiamaa S.
Format: Article
Language:English
Subjects:
CECs
P. falciparum
Severe malaria
Vascular damage
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Summary:Plasmodium falciparum infection is associated with diffuse vascular dys-regulation. Levels of blood circulating endothelial cells (CECs; CD146+CD45−) are a marker of vascular injury. This study aimed to measure blood CECs by flow cytometery in patients with acute malaria infection before and after treatment and to evaluate the prognostic value of that measurement for that disease. The subjects were allocated into: Group I: uncomplicated malaria (UM, n = 32), Group II: severe malaria (SM, n = 12), Group III: the treated UM (TUM, n = 32), Group IV: the treated SM (TSM, n = 12) and Group V: healthy controls (HC, n = 25). Before treatment, SM patients showed the highest mean number of CECs (30,658.3 ± 2658.2/5 × 106 peripheral blood mononuclear cells (PBMCs)), followed by UM patients (19,481.56 ± 866.83/5x106PBMCs) and both groups were significantly higher than HC (2034 ± 300.59/5x106PBMCs, P 
ISSN:1383-5769
1873-0329
DOI:10.1016/j.parint.2019.101926