Remaining Effect of Influenza Vaccines Received in Prior Seasons

This study evaluates the remaining effect of influenza vaccines received in the 5 prior seasons. During 7 influenza seasons, 8933 patients were enrolled and 47% were confirmed for influenza. Compared with unvaccinated individuals in the current and 5 prior seasons, vaccination was protective when th...

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Bibliographic Details
Published in:The Journal of infectious diseases 2019-08, Vol.220 (7), p.1136-1140
Main Authors: Martínez-Baz, Iván, Navascués, Ana, Casado, Itziar, Aguinaga, Aitziber, Ezpeleta, Carmen, Castilla, Jesús
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Case-Control Studies
Child
Chronic illnesses
Cohort Studies
Female
Humans
Immunization
Influenza
Influenza A Virus, H1N1 Subtype - genetics
Influenza A Virus, H3N2 Subtype - genetics
Influenza B virus - genetics
Influenza Vaccines - therapeutic use
Influenza, Human - prevention & control
Male
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction
Seasons
Treatment Outcome
Vaccination
VACCINES
Young Adult
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Summary:This study evaluates the remaining effect of influenza vaccines received in the 5 prior seasons. During 7 influenza seasons, 8933 patients were enrolled and 47% were confirmed for influenza. Compared with unvaccinated individuals in the current and 5 prior seasons, vaccination was protective when the last dose had been received in the current season (40% [95% confidence interval {CI}, 32%–47%]), and 1 (42% [95% CI, 27%–54%]), 2–3 (35% [95% CI, 16%–49%]), or 4–5 seasons (31% [95% CI, 4%–51%]) prior. This effect lasted for fewer seasons in the elderly and in patients with chronic conditions. On average, several recent prior doses were as protective as current-season vaccination.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiz266