An evaluation of the different biomarkers to discriminate bleeding in Crimean-Congo Hemorrhagic Fever

• Published in: Ticks and tick-borne diseases 2019-08, Vol.10 (5), p.997-1002
• Main Authors: Büyüktuna, Seyit Ali, Doğan, Halef Okan, Unlusavuran, Meltem, Bakir, Mehmet
• Format: Article
• Language: English
• Subjects: CCHF; Ferritin; Iron; UIBC
• ISSN: 1877-959X; 1877-9603
• DOI: 10.1016/j.ttbdis.2019.05.008

Crimean-Congo Hemorrhagic Fever (CCHF) is an acute viral hemorrhagic disease. In this study, an evaluation was made of the potential use of iron metabolism and liver function biomarkers to estimate the bleeding status in CCHF patients. This prospective study was conducted in Cumhuriyet University, Turkey. Only patients with confirmed CCHF were enrolled in the study. The study subjects comprised 40 CCHF patients and 37 healthy control subjects. Serum iron, unsaturated iron binding capacity (UIBC), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels were determined using the colorimetric method. Serum ferritin levels were measured using the electrochemiluminescent method. The serum ferritin (p = 0.037), AST (p = 0.0002), ALT (p = 0.002), LDH (p = 0.0005) and aPTT (p = 0.001) values were higher in patients with bleeding than in patients without bleeding. Receiving operating characteristic analyses were applied for the area under the curve (AUC) values for ferritin, aPTT, and AST to discriminate the bleeding status in patients, an these were determined as 0.717, 0.819, and 0.882, respectively. A cut-off value of 149 U/L for AST was obtained to discriminate the bleeding condition in CCHF patients. Higher ferritin (p