Ameliorative Effect of High-Dose Vitamin C Administration on Dextran Sulfate Sodium-Induced Colitis Mouse Model

Vitamin C is a natural nutrient with antioxidant properties and is used as a health supplement. In this study, we examined the effects of intraperitoneal administration of high-dose vitamin C (4 g/kg) on dextran sodium sulfate (DSS)-induced ulcerative colitis. We prepared a mouse ulcerative colitis...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2019/06/01, Vol.42(6), pp.954-959
Main Authors: Kondo, Kanako, Hiramoto, Keiichi, Yamate, Yurika, Goto, Kenji, Sekijima, Hidehisa, Ooi, Kazuya
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Ascorbic acid
Blood levels
collagen type I
collagen type III
Colon
Dextran
dextran sodium sulfate-induced ulcerative colitis
Dextran sulfate
DNA nucleotidylexotransferase
Fibroblasts
Hydrogen peroxide
Inflammatory bowel disease
Interleukin 6
Iron
Mice
Sodium
Sodium sulfate
Sulfates
Tumor necrosis factor-α
Ulcerative colitis
Vitamin C
Vitamin E
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Summary:Vitamin C is a natural nutrient with antioxidant properties and is used as a health supplement. In this study, we examined the effects of intraperitoneal administration of high-dose vitamin C (4 g/kg) on dextran sodium sulfate (DSS)-induced ulcerative colitis. We prepared a mouse ulcerative colitis model by administering DSS for 7 d along with high-dose vitamin C each day during DSS treatment. Ulcerative colitis induced by DSS was ameliorated by high-dose vitamin C administration. Blood levels of interleukin-6, tumor necrosis factor-α, hydrogen peroxide (H2O2), and iron were elevated in DSS-treated mice but lowered by high-dose vitamin C administration. Contrarily, the levels of H2O2 and iron and the numbers of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells in the colon were further increased by high-dose vitamin C administration. The expression levels of fibroblasts, collagen type I, and collagen type III decreased in the DSS-treated mice but increased in mice administered high-dose vitamin C. These results suggest that high-dose vitamin C administration can improve ulcerative colitis.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b18-00967