HITM-SIR: phase Ib trial of intraarterial chimeric antigen receptor T-cell therapy and selective internal radiation therapy for CEA+ liver metastases

Effective chimeric antigen receptor-modified T-cell (CAR-T) therapy for liver metastases (LM) will require innovative solutions to ensure efficient delivery and minimization of systemic toxicity. We previously demonstrated the safety of CAR-T hepatic artery infusions (HAI). We subsequently conducted...

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Bibliographic Details
Published in:	Cancer gene therapy 2020-05, Vol.27 (5), p.341-355
Main Authors:	Katz, Steven C., Hardaway, John, Prince, Ethan, Guha, Prajna, Cunetta, Marissa, Moody, Ashley, Wang, Li Juan, Armenio, Vincent, Espat, N. Joseph, Junghans, Richard P.
Format:	Article
Language:	English
Subjects:	13/31 14/19 14/63 38/77 38/90 59/57 59/78 631/67/1059/2325 631/67/1059/602 96/106 96/21 96/95 Adult Aged Antigens Biomedical and Life Sciences Biomedicine Brachytherapy - methods Carcinoembryonic antigen Carcinoembryonic Antigen - metabolism Cell therapy Cerebrospinal fluid Chimeric antigen receptors Clinical trials Colonic Neoplasms - immunology Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colonic Neoplasms - therapy Combined Modality Therapy - methods Cytokines Female Follow-Up Studies Gene Expression Gene Therapy GPI-Linked Proteins - antagonists & inhibitors GPI-Linked Proteins - metabolism Granulocyte-macrophage colony-stimulating factor Hepatic artery Hepatocytes Humans Immunotherapy, Adoptive - methods Infusions, Intra-Arterial Liver Liver - blood supply Liver - immunology Liver - pathology Liver - radiation effects Liver Neoplasms - immunology Liver Neoplasms - mortality Liver Neoplasms - secondary Liver Neoplasms - therapy Lymphocytes T Male Metastases Metastasis Middle Aged Neurotoxicity Pancreatic Neoplasms - immunology Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy PD-L1 protein Radiation therapy Receptors, Chimeric Antigen - immunology Rectal Neoplasms - immunology Rectal Neoplasms - mortality Rectal Neoplasms - pathology Rectal Neoplasms - therapy Response Evaluation Criteria in Solid Tumors
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