Decarboxylative [4+2] annulation of arylglyoxylic acids with internal alkynes using the anodic ruthenium catalysis

A new electrochemical decarboxylative [4+2] annulation of arylglyoxylic acids with internal alkynes involving C-H functionalization by means of a cooperative anode and ruthenium catalysis is presented. This reaction represents a mechanistically novel strategy as an ideal supplement to the decarboxyl...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-06, Vol.55 (5), p.7251-7254
Main Authors: Luo, Mu-Jia, Zhang, Ting-Ting, Cai, Fang-Jun, Li, Jin-Heng, He, De-Liang
Format: Article
Language:English
Subjects:
Alkynes
Catalysis
Chemical reactions
Organic chemistry
Oxidation
Reagents
Ruthenium
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Summary:A new electrochemical decarboxylative [4+2] annulation of arylglyoxylic acids with internal alkynes involving C-H functionalization by means of a cooperative anode and ruthenium catalysis is presented. This reaction represents a mechanistically novel strategy as an ideal supplement to the decarboxylative [4+2] annulation methodology by employing an electrooxidative process to avoid the use of an additional external oxidizing reagent and utilizing H 2 O as the carboxyl oxygen atom source to be engaged in the synthesis of 1 H -isochromen-1-ones. Mechanistically novel decarboxylative [4+2] annulation of arylglyoxylic acids with internal alkynes using the anodic ruthenium catalysis is presented.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc03210j