Lactobacillus sp. improved microbiota and metabolite profiles of aging rats

[Display omitted] Aging is closely associated with altered gut function and composition, in which elderly were reported with reduced gut microbiota diversity and increased incidence of age-related diseases. Probiotics have been shown to exert beneficial health-promoting effects through modulation of...

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Published in:Pharmacological research 2019-08, Vol.146, p.104312-104312, Article 104312
Main Authors: Hor, Yan-Yan, Lew, Lee-Ching, Jaafar, Mohamad Hafis, Lau, Amy Sie-Yik, Ong, Jia-Sin, Kato, Tamotsu, Nakanishi, Yumiko, Azzam, Ghows, Azlan, Azali, Ohno, Hiroshi, Liong, Min-Tze
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Aging - physiology
Animals
Colon - metabolism
Colon - microbiology
Cytokines - metabolism
Feces - microbiology
Gastrointestinal Microbiome - physiology
Lactobacillus
Lactobacillus - physiology
Male
Metabolite
Microbiota
Microbiota - physiology
Models, Animal
Probiotic
Probiotics - metabolism
Rats
Rats, Sprague-Dawley
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Summary:[Display omitted] Aging is closely associated with altered gut function and composition, in which elderly were reported with reduced gut microbiota diversity and increased incidence of age-related diseases. Probiotics have been shown to exert beneficial health-promoting effects through modulation of intestinal microflora biodiversity, thus the effects of probiotics administration on D-galactose (D-gal) senescence-induced rat were evaluated based on the changes in gut microbiota and metabolomic profiles. Upon senescence induction, the ratio of Firmicutes/ Bacteroidetes was significantly lowered, while treatment with Lactobacillus helveticus OFS 1515 and L. fermentum DR9 increased the ratio at the phylum level (P 
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2019.104312