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Long-term Prognostic Impact of Chromosome Abnormalities in Clear Cell Renal Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC) shows variable chromosomal abnormalities. The aim of this study was to assess the prognostic role of ccRCC chromosomal abnormalities in a single-center cohort with an extended follow-up. A systematic cytogenetic analysis was performed in 283 consecutive surgic...
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| Published in: | Anticancer research 2019-06, Vol.39 (6), p.2757-2765 |
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| container_end_page | 2765 |
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| container_title | Anticancer research |
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| creator | Palumbo, Carlotta Furlan, Maria Balzarini, Piera Zanotelli, Tiziano Cozzoli, Alberto Veccia, Alessandro Francavilla, Simone Zamboni, Stefania Tardanico, Regina Simeone, Claudio Antonelli, Alessandro |
| description | Clear cell renal cell carcinoma (ccRCC) shows variable chromosomal abnormalities. The aim of this study was to assess the prognostic role of ccRCC chromosomal abnormalities in a single-center cohort with an extended follow-up.
A systematic cytogenetic analysis was performed in 283 consecutive surgically-treated patients for renal masses between 1997 and 2002. Kaplan-Meier and multivariable Cox regression (MCR) models were used to calculate cancer specific survival (CSS).
Among 174 ccRCC patients, the most common abnormality was deletion in chromosome 3 (54.6%). At a median follow-up of 119 months, 38 patients (21.8%) died from RCC. At MCR models, worse CSS was independently predicted by deletions in chromosomes 2, 19, 20 or 22 and insertions in chromosome 18.
Specific ccRCC chromosomal abnormalities are independently associated with worse CSS. Cytogenetic evaluation may direct further genetic analysis for personalized prognostic stratification. |
| doi_str_mv | 10.21873/anticanres.13402 |
| format | article |
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A systematic cytogenetic analysis was performed in 283 consecutive surgically-treated patients for renal masses between 1997 and 2002. Kaplan-Meier and multivariable Cox regression (MCR) models were used to calculate cancer specific survival (CSS).
Among 174 ccRCC patients, the most common abnormality was deletion in chromosome 3 (54.6%). At a median follow-up of 119 months, 38 patients (21.8%) died from RCC. At MCR models, worse CSS was independently predicted by deletions in chromosomes 2, 19, 20 or 22 and insertions in chromosome 18.
Specific ccRCC chromosomal abnormalities are independently associated with worse CSS. Cytogenetic evaluation may direct further genetic analysis for personalized prognostic stratification.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.13402</identifier><identifier>PMID: 31177111</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Abnormalities ; Aged ; Cancer ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - mortality ; Carcinoma, Renal Cell - surgery ; Chromosome 18 ; Chromosome 3 ; Chromosome Aberrations ; Chromosome Deletion ; Chromosomes ; Chromosomes, Human - genetics ; Clear cell-type renal cell carcinoma ; Clonal deletion ; Cytogenetics ; Female ; Genetic analysis ; Health risk assessment ; Humans ; Kaplan-Meier Estimate ; Kidney cancer ; Kidney Neoplasms - genetics ; Kidney Neoplasms - mortality ; Kidney Neoplasms - surgery ; Male ; Middle Aged ; Mutagenesis, Insertional ; Prognosis ; Proportional Hazards Models ; Regression analysis ; Retrospective Studies ; Treatment Outcome</subject><ispartof>Anticancer research, 2019-06, Vol.39 (6), p.2757-2765</ispartof><rights>Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright International Institute of Anticancer Research Jun 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-b4c760f5a424e13c9237ec1ff8e332dcaa73266dd5e293903b104d0ad09d39c43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31177111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palumbo, Carlotta</creatorcontrib><creatorcontrib>Furlan, Maria</creatorcontrib><creatorcontrib>Balzarini, Piera</creatorcontrib><creatorcontrib>Zanotelli, Tiziano</creatorcontrib><creatorcontrib>Cozzoli, Alberto</creatorcontrib><creatorcontrib>Veccia, Alessandro</creatorcontrib><creatorcontrib>Francavilla, Simone</creatorcontrib><creatorcontrib>Zamboni, Stefania</creatorcontrib><creatorcontrib>Tardanico, Regina</creatorcontrib><creatorcontrib>Simeone, Claudio</creatorcontrib><creatorcontrib>Antonelli, Alessandro</creatorcontrib><title>Long-term Prognostic Impact of Chromosome Abnormalities in Clear Cell Renal Cell Carcinoma</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Clear cell renal cell carcinoma (ccRCC) shows variable chromosomal abnormalities. The aim of this study was to assess the prognostic role of ccRCC chromosomal abnormalities in a single-center cohort with an extended follow-up.
A systematic cytogenetic analysis was performed in 283 consecutive surgically-treated patients for renal masses between 1997 and 2002. Kaplan-Meier and multivariable Cox regression (MCR) models were used to calculate cancer specific survival (CSS).
Among 174 ccRCC patients, the most common abnormality was deletion in chromosome 3 (54.6%). At a median follow-up of 119 months, 38 patients (21.8%) died from RCC. At MCR models, worse CSS was independently predicted by deletions in chromosomes 2, 19, 20 or 22 and insertions in chromosome 18.
Specific ccRCC chromosomal abnormalities are independently associated with worse CSS. Cytogenetic evaluation may direct further genetic analysis for personalized prognostic stratification.</description><subject>Abnormalities</subject><subject>Aged</subject><subject>Cancer</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Carcinoma, Renal Cell - mortality</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>Chromosome 18</subject><subject>Chromosome 3</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Deletion</subject><subject>Chromosomes</subject><subject>Chromosomes, Human - genetics</subject><subject>Clear cell-type renal cell carcinoma</subject><subject>Clonal deletion</subject><subject>Cytogenetics</subject><subject>Female</subject><subject>Genetic analysis</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Kidney cancer</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - mortality</subject><subject>Kidney Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutagenesis, Insertional</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkDtPwzAUhS0EoqXwA1iQJRaWFF_fJE7GKuJRqRIIwcISuY5TUsV2sZOBf0_6ACSme4fvHB19hFwCm3LIBN5K2zVKWq_DFDBm_IiMQeQQiQTZMRkznrBIMJaMyFkIa8bSNM_wlIwQQAgAGJP3hbOrqNPe0GfvVtaFoZHOzUaqjrqaFh_eGRec0XS2tM4b2TZdowNtLC1aLT0tdNvSF21lu38L6VVjnZHn5KSWbdAXhzshb_d3r8VjtHh6mBezRaRQ8C5axkqkrE5kzGMNqHKOQiuo60wj8kpJKZCnaVUlmueYM1wCiysmK5ZXmKsYJ-Rm37vx7rPXoStNE9QwRVrt-lByHvOM5ylkA3r9D1273g_Tt1QCYisMBwr2lPIuBK_rcuMbI_1XCazciS__xJc78UPm6tDcL42ufhM_pvEbxsyAGw</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Palumbo, Carlotta</creator><creator>Furlan, Maria</creator><creator>Balzarini, Piera</creator><creator>Zanotelli, Tiziano</creator><creator>Cozzoli, Alberto</creator><creator>Veccia, Alessandro</creator><creator>Francavilla, Simone</creator><creator>Zamboni, Stefania</creator><creator>Tardanico, Regina</creator><creator>Simeone, Claudio</creator><creator>Antonelli, Alessandro</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>Long-term Prognostic Impact of Chromosome Abnormalities in Clear Cell Renal Cell Carcinoma</title><author>Palumbo, Carlotta ; 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The aim of this study was to assess the prognostic role of ccRCC chromosomal abnormalities in a single-center cohort with an extended follow-up.
A systematic cytogenetic analysis was performed in 283 consecutive surgically-treated patients for renal masses between 1997 and 2002. Kaplan-Meier and multivariable Cox regression (MCR) models were used to calculate cancer specific survival (CSS).
Among 174 ccRCC patients, the most common abnormality was deletion in chromosome 3 (54.6%). At a median follow-up of 119 months, 38 patients (21.8%) died from RCC. At MCR models, worse CSS was independently predicted by deletions in chromosomes 2, 19, 20 or 22 and insertions in chromosome 18.
Specific ccRCC chromosomal abnormalities are independently associated with worse CSS. Cytogenetic evaluation may direct further genetic analysis for personalized prognostic stratification.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>31177111</pmid><doi>10.21873/anticanres.13402</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Aged Cancer Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - surgery Chromosome 18 Chromosome 3 Chromosome Aberrations Chromosome Deletion Chromosomes Chromosomes, Human - genetics Clear cell-type renal cell carcinoma Clonal deletion Cytogenetics Female Genetic analysis Health risk assessment Humans Kaplan-Meier Estimate Kidney cancer Kidney Neoplasms - genetics Kidney Neoplasms - mortality Kidney Neoplasms - surgery Male Middle Aged Mutagenesis, Insertional Prognosis Proportional Hazards Models Regression analysis Retrospective Studies Treatment Outcome |
| title | Long-term Prognostic Impact of Chromosome Abnormalities in Clear Cell Renal Cell Carcinoma |
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