A single amino acid change in hemagglutinin reduces the cross-reactivity of antiserum against an equine influenza vaccine strain

Equine influenza virus is an important pathogen for the horse industry because of its economic impact, and vaccination is a key control measure. Our previous work suggested that a mutation at position 144 in the hemagglutinin of Florida sublineage clade 2 viruses reduces the cross-neutralizing activ...

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Bibliographic Details
Published in:Archives of virology 2019-09, Vol.164 (9), p.2355-2358
Main Authors: Nemoto, Manabu, Yamayoshi, Seiya, Bannai, Hiroshi, Tsujimura, Koji, Kokado, Hiroshi, Kawaoka, Yoshihiro, Yamanaka, Takashi
Format: Article
Language:English
Subjects:
Amino acid substitution
Antisera
Biomedical and Life Sciences
Biomedicine
Brief Report
Cross-reactivity
Hemagglutinins
Infectious Diseases
Influenza
Medical Microbiology
Vaccination
Vaccines
Virology
Viruses
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Summary:Equine influenza virus is an important pathogen for the horse industry because of its economic impact, and vaccination is a key control measure. Our previous work suggested that a mutation at position 144 in the hemagglutinin of Florida sublineage clade 2 viruses reduces the cross-neutralizing activity of antiserum against a former vaccine strain. To confirm this suggestion, here, we generated viruses by reverse genetics. Antibody titers against the mutated viruses were one-tenth to one-sixteenth of those against the former vaccine strain. Our findings confirm that this single amino acid substitution reduces the cross-reactivity of antiserum against this former Japanese vaccine.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-019-04328-4