A functional substitution in the L‐aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway

Objective Heightened somatic symptoms are reported by a wide range of patients with chronic pain and have been associated with emotional distress and physical dysfunction. Despite their clinical significance, molecular mechanisms leading to their manifestation are not understood. Methods We used an...

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Bibliographic Details
Published in:	Annals of neurology 2019-08, Vol.86 (2), p.168-180
Main Authors:	Khoury, Samar, Piltonen, Marjo H., Ton, Anh‐Tien, Cole, Tiffany, Samoshkin, Alexander, Smith, Shad B., Belfer, Inna, Slade, Gary D., Fillingim, Roger B., Greenspan, Joel D., Ohrbach, Richard, Maixner, William, Neely, G. Gregory, Serohijos, Adrian W. R., Diatchenko, Luda
Format:	Article
Language:	English
Subjects:	Adolescent Adult Amino acid substitution Amino Acid Substitution - genetics Arginine Aromatic-L-Amino-Acid Decarboxylases - genetics Case-Control Studies Chronic pain Enzymes Facial Pain - diagnosis Facial Pain - genetics Female Gene polymorphism Genetic Association Studies - methods Genomics Glutamine HEK293 Cells Humans Male Medically Unexplained Symptoms Middle Aged Molecular dynamics Molecular modelling Neural coding Nucleotides Pain Polymorphism Prospective Studies Protein Structure, Secondary Serotonin Serotonin - genetics Signal Transduction - genetics Signs and symptoms Single-nucleotide polymorphism Substitutes Young Adult
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