The influence of body temperature on tissue stiffness, blood perfusion, and water diffusion in the mouse brain

[Display omitted] While hypothermia of the brain is used to reduce neuronal damage in patients with conditions such as traumatic brain injury or stroke, little is known about how temperature affects the biophysical properties of in vivo brain tissue. Therefore, we measured shear wave speed (SWS), ap...

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Bibliographic Details
Published in:Acta biomaterialia 2019-09, Vol.96, p.412-420
Main Authors: Bertalan, Gergely, Boehm-Sturm, Philipp, Schreyer, Stefanie, Morr, Anna-Sophie, Steiner, Barbara, Tzschätzsch, Heiko, Braun, Jürgen, Guo, Jing, Sack, Ingolf
Format: Article
Language:English
Subjects:
Blood flow
Body temperature
Brain
Brain damage
Brain stiffness
Cerebral blood flow
Cortex
Diencephalon
Diffusion
Diffusion coefficient
Diffusion rate
Head injuries
Hypothermia
Magnetic resonance
Magnetic resonance imaging
Microvasculature
Mouse
Multifrequency MRE
Neuroimaging
Perfusion
Recording
Rodents
S waves
Spin labeling
Stiffness
Temperature
Temperature effects
Tissues
Tomoelastography
Traumatic brain injury
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Summary:[Display omitted] While hypothermia of the brain is used to reduce neuronal damage in patients with conditions such as traumatic brain injury or stroke, little is known about how temperature affects the biophysical properties of in vivo brain tissue. Therefore, we measured shear wave speed (SWS), apparent diffusion coefficient (ADC), and cerebral blood flow (CBF) in the mouse brain at different body temperatures to investigate the relationship between temperature and tissue stiffness, water diffusion, and blood perfusion in the living brain. Multifrequency magnetic resonance elastography (MRE), diffusion-weighted imaging (DWI), and arterial spin labeling (ASL) were performed in seven mice while increasing and recording body temperature from hypothermia (28–30 °C) to normothermia (36–38 °C). SWS, ADC, and CBF were analyzed in regions of whole brain, cortex, hippocampus, and diencephalon. Our results show that SWS decreases while ADC and CBF increase from hypothermia to normothermia (whole brain SWS: −6.2%, ADC: +34.0%, CBF: +80.2%; cortex SWS: −10.1%, ADC: +30.9%, CBF: +82.4%; all p > 0.05). We found a significant inverse correlation between SWS and both ADC and CBF in all analyzed regions except diencephalon (whole brain SWS-ADC: r = −0.8, p 
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2019.06.034