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Exposure: Staphylococcus aureus skin colonization predisposes to food allergy in the Learning Early about Allergy to Peanut (LEAP) and LEAP-On studies

[...]7 of the 319 subjects were excluded because they had an oral response to peanut on initial challenge, and 9 of the 319 subjects of the peanut consumer group had an oral response to peanut. Because peanut reactions can be life-threatening and reactions can occur during initial food challenge and...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2019-08, Vol.144 (2), p.404-406
Main Authors: Cook-Mills, Joan M., Kaplan, Mark H., Turner, Matthew J., Kloepfer, Kirsten M., Kumar, Rajesh
Format: Article
Language:English
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Summary:[...]7 of the 319 subjects were excluded because they had an oral response to peanut on initial challenge, and 9 of the 319 subjects of the peanut consumer group had an oral response to peanut. Because peanut reactions can be life-threatening and reactions can occur during initial food challenge and oral immunotherapy protocols, it is critical to identify risk factors for peanut-induced allergic reactions. For those patients in whom induction of tolerance to peanut failed, skin exposures to S aureus or other environmental factors associated with S aureus might have contributed to development of peanut allergy. [...]these LEAP and LEAP-On analyses demonstrate that early-life cutaneous skin exposure to S aureus and early-life eczema associate with subsequent food allergy development, including peanut-consuming children who had food allergy during early introduction of peanut. The study suggest that S aureus colonization or factors associated with S aureus colonization act as adjuvants that block induction of oral tolerance and promote sensitization to allergens introduced through epicutaneous exposure. [...]it suggests that S aureus colonization can negatively affect clinical approaches to induce oral tolerance to peanut and potentially other allergens in some patients.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2019.06.014