Clinical efficacy of a new cetylpyridinium chloride‐hyaluronic acid–based mouthrinse compared to chlorhexidine and placebo mouthrinses—A 21‐day randomized clinical trial

Objective To compare the effectiveness of a novel cetylpyridinium chloride (CPC)‐hyaluronic acid (HA)–based mouthrinse with chlorhexidine (CHX) and placebo mouthrinses in preventing plaque and gingivitis. The secondary outcomes were calculus, extrinsic stains, oral malodour and occurrence of adverse...

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Bibliographic Details
Published in:International journal of dental hygiene 2020-02, Vol.18 (1), p.116-123
Main Authors: Tadakamadla, Santosh Kumar, Bharathwaj, Venkata V., Duraiswamy, Prabu, Sforza, Chiarella, Tartaglia, Gianluca M.
Format: Article
Language:English
Subjects:
adverse effects
Anti-Infective Agents, Local
Cetylpyridinium
Cetylpyridinium chloride
Chlorhexidine
Clinical trials
Dental Plaque Index
Dentistry
Double-Blind Method
Gingival index
Gingivitis
Humans
Hyaluronic Acid
mouthrinse
Mouthwashes
Plaque index
Prophylaxis
Stains & staining
Teeth
therapeutic use
Treatment Outcome
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Summary:Objective To compare the effectiveness of a novel cetylpyridinium chloride (CPC)‐hyaluronic acid (HA)–based mouthrinse with chlorhexidine (CHX) and placebo mouthrinses in preventing plaque and gingivitis. The secondary outcomes were calculus, extrinsic stains, oral malodour and occurrence of adverse events. Methods A 21‐day randomized, double‐blind, three‐arm parallel study with random allocation of young dental students to any of the three mouthrinse groups. Thorough prophylaxis was done at baseline followed by a baseline examination for oral malodour, extrinsic stains, calculus, gingivitis and plaque by a single examiner. All the subjects used the allocated mouthrinse twice daily for 21 days and were examined again at the end of the experimental period. They were also interviewed for adverse events. Change in the scores of clinical indices was calculated and compared between the groups. Results A total of 75 subjects were included and completed the experiment. There was a significant difference for change in plaque index scores between the groups (P = .015); subjects in the placebo group experienced higher levels of plaque accumulation than the other groups. Teeth staining increased in the CHX (P 
ISSN:1601-5029
1601-5037
DOI:10.1111/idh.12413