Body mass index (BMI) in major depressive disorder and its effects on depressive symptomatology and antidepressant response

•Weight gain during study is associated with better therapy outcome.•BMI was mainly associated with neurovegetative and cognitive symptoms of MDD.•Overweight patients showed best response to antidepressant therapy. Obesity is one of the most prevalent somatic comorbidities of Major Depressive Disord...

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Bibliographic Details
Published in:Journal of affective disorders 2019-09, Vol.256, p.524-531
Main Authors: Dreimüller, Nadine, Lieb, Klaus, Tadić, André, Engelmann, Jan, Wollschläger, Daniel, Wagner, Stefanie
Format: Article
Language:English
Subjects:
Antidepressant
BMI
Depressive symptoms
Major depressive disorder
Prediction
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Summary:•Weight gain during study is associated with better therapy outcome.•BMI was mainly associated with neurovegetative and cognitive symptoms of MDD.•Overweight patients showed best response to antidepressant therapy. Obesity is one of the most prevalent somatic comorbidities of Major Depressive Disorder (MDD). We aimed to investigate the relationship between body mass index (BMI) and MDD, the symptomatology of the disorder as well as the outcome of antidepressant treatment. Early medication change (EMC) trial participants with BMI measurement (n = 811) were categorized according to WHO-criteria in normal or low weight (BMI 
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2019.06.067